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Zero E-waste: Regulatory impediments and blockchain imperatives
Mengjun Chen, Oladele A. Ogunseitan
《环境科学与工程前沿(英文)》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1402-x
关键词: Blockchain E-waste Regulatory Policy Copyright Laws Repair-Reuse-Remanufacture Toxicity
The regulatory sciences for stem cell-based medicinal products
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 190-200 doi: 10.1007/s11684-014-0323-5
Over the past few years, several new achievements have been made from stem cell studies, many of which have moved up from preclinical stages to early, or from early to middle or late, stages thanks to relatively safe profile and preliminary evidence of effectiveness. Moreover, some stem cell-based products have been approved for marketing by different national regulatory authorities. However, many critical issues associated mainly with incomplete understanding of stem cell biology and the relevant risk factors, and lack of effective regulations still exist and need to be urgently addressed, especially in countries where establishment of appropriate regulatory system just commenced. More relevantly, the stem cell regulatory sciences need to be established or improved to more effectively evaluate quality, safety and efficacy of stem cell products, and for building up the appropriate regulatory framework. In this review, we summarize some new achievements in stem cell studies, especially the preclinical and clinical studies, the existing regulations, and the associated challenges, and we then propose some considerations for improving stem cell regulatory sciences with a goal of promoting the steadfast growth of the well-regulated stem cell therapies abreast of evolvement of stem cell sciences and technologies.
关键词: stem cell-based medicinal products (SCMPs) stem cell therapy (SCT) safety effectiveness standards guidelines regulatory science
Disinfection byproducts in drinking water and regulatory compliance: A critical review
Xiaomao WANG,Yuqin MAO,Shun TANG,Hongwei YANG,Yuefeng F. XIE
《环境科学与工程前沿(英文)》 2015年 第9卷 第1期 页码 3-15 doi: 10.1007/s11783-014-0734-1
关键词: Disinfection byproducts (DBPs) drinking water standards regulatory compliance alternative disinfection information collection rule (ICR) emerging DBPs
美国高温气冷堆现状 Review
Andrew C. Kadak
《工程(英文)》 2016年 第2卷 第1期 页码 119-123 doi: 10.1016/J.ENG.2016.01.026
2005 年,美国国会通过了《2005年能源政策法案》,该法案授权在2021年之前建造和运行一个高温气冷堆(HTGR)。在美国国内专家对未来核技术发展方向进行了多年的研究后,该法案才得以通过。作为该法案的结果,美国国会设立了名为“下一代核电站”的项目,这是一种为制氢提供工艺用热的HTGR。尽管HTGR被寄予了很高的期望,但其现状仅限于完成关于先进燃料、石墨和其他材料的研究计划,并不是如国会在2005年提出的建造一个示范电站。HTGR 发展目标降低背后有许多原因,包括:用于研究的政府资金不足,对反应堆不切实际的高温要求,对“氢”经 济需求的延迟,来自轻水冷却的小型模块反应堆的竞争,业主公司对新技术的兴趣较低,美国天然气价格过低,以及美国对非水冷反应堆许可证申请的具有挑战性的流程等。
Liver cell therapies: cellular sources and grafting strategies
《医学前沿(英文)》 2023年 第17卷 第3期 页码 432-457 doi: 10.1007/s11684-023-1002-1
关键词: liver regeneration hepatocytes cholangiocytes stem cells organoids regulatory mechanisms transplantation/grafting strategies
Chaoyang FU,Wangfeng LI
《环境科学与工程前沿(英文)》 2015年 第9卷 第2期 页码 310-316 doi: 10.1007/s11783-014-0658-9
关键词: environmental policy distributed environment policy distributed parameter model lumped parameter model
《农业科学与工程前沿(英文)》 2021年 第8卷 第2期
Metabolites, especially secondary metabolites, are very important in the adaption of tea plants and the quality of tea products. Here, we focus on the seasonal variation in metabolites of fresh tea shoots and their regulatory mechanism at the transcriptional level. The metabolic profiles of fresh tea shoots of 10 tea accessions collected in spring, summer, and autumn were analyzed using ultra-performance liquid chromatography coupled with quadrupole-obitrap mass spectrometry. We focused on the metabolites and key genes in the phenylpropanoid/flavonoid pathway integrated with transcriptome analysis. Multivariate statistical analysis indicates that metabolites were distinctly different with seasonal alternation. Flavonoids, amino acids, organic acids and alkaloids were the predominant metabolites. Levels of most key genes and downstream compounds in the flavonoid pathway were lowest in spring but the catechin quality index was highest in spring. The regulatory pathway was explored by constructing a metabolite correlation network and a weighted gene co-expression network.
China’s policy framework for carbon capture, utilization and storage: Review, analysis, and outlook
《能源前沿(英文)》 2023年 第17卷 第3期 页码 400-411 doi: 10.1007/s11708-023-0862-z
关键词: carbon capture utilization and storage (CCUS) policy content analysis China
Yinglie ZHOU, Cunkuan BAO,
《环境科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 82-90 doi: 10.1007/s11783-010-0004-9
关键词: Policy Environmental Assessment (PEA) policy hierarchy PEA hierarchy methodological framework
Translating evidence into policy in China: opportunities and challenges
Jiyao Wang, Xuejuan Jin
《医学前沿(英文)》 2011年 第5卷 第3期 页码 315-320 doi: 10.1007/s11684-011-0146-6
关键词: clinical epidemiology evidence-based decision making policy
调节性T细胞及其在抗肿瘤免疫疗法中的临床应用 Review
解丰, 梁瑞, 李丹, 李斌
《工程(英文)》 2019年 第5卷 第1期 页码 132-139 doi: 10.1016/j.eng.2018.12.002
癌症是可能危及生命的疾病,特点在于肿瘤细胞在宿主身上无限增殖。最近,因其具有预防肿瘤进展和转移的巨大潜力,免疫疗法受到越来越多研究者的关注。调节性T 细胞(Treg)是对维持宿主免疫稳态起重要作用的抑制性CD4+ T 细胞的一个亚群。调节性T 细胞缺陷可引起严重的自身免疫、过敏和自身炎症等疾病。调节性T 细胞通常富集在肿瘤微环境中,而大量免疫抑制调节性T细胞往往表明预后较差。因此,人们对调节性T 细胞的功能及其在抗肿瘤免疫疗法中的临床应用再次产生了兴趣。越来越多的策略关注调节性T 细胞的消耗,这在抗肿瘤免疫方面似乎有效。预计调节性T 细胞靶向策略与其他疗法(如嵌合抗原受体T 细胞疗法或免疫检查点阻断)联用将为提高抗肿瘤疗效带来重大机遇。
Moving policy and regulation forward for single-use plastic alternatives
《环境科学与工程前沿(英文)》 2021年 第15卷 第3期 doi: 10.1007/s11783-021-1423-5
关键词: Single-use plastic alternatives Policy Regulation Sustainable development
Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN
《农业科学与工程前沿(英文)》 页码 215-230 doi: 10.15302/J-FASE-2021382
关键词: harvest season metabolites tea shoots transcriptomics untargeted metabolomics
药品监管科学推动中国新冠病毒疫苗研发概述 Review
黄志明, 付志浩, 王军志
《工程(英文)》 2022年 第10卷 第3期 页码 127-132 doi: 10.1016/j.eng.2022.01.001
监管科学是一门综合应用自然科学、社会科学和人文科学,开发新工具、新标准和新方法,以评估受监管产品的安全性、有效性、质量和性能的学科。监管科学研究的根本目的是为行政决策提供技术支撑。在甲型H1N1流感、严重急性呼吸综合征(SARS)和中东呼吸综合征(MERS)等传染病大流行期间,监管科学研究有力支持了抗病毒药物和疫苗的研发。特别在新型冠状病毒(简称新冠病毒)肺炎(COVID-19)疫情大流行期间,药品监管科学支持下的疫苗研发在疫情防控中发挥了重要作用。本文总结了中国疫苗产业、新冠病毒疫苗研发以及疫苗监管科学发展的总体概况。此外,本文重点从国家规划、法律法规、技术指南、质量控制和疫苗上市后监管等方面,回顾和分析了监管科学研究为推动中国新冠病毒疫苗研发所发挥的重要作用。本文为当前大流行阶段以及后疫情时代的疫苗研发策略制定提供参考,并为将来如何更好地应对新发和再发传染病提供借鉴和指导。
Towards the sustainable intensification of agriculture—a systems approach to policy formulation
Leslie G. FIRBANK
《农业科学与工程前沿(英文)》 2020年 第7卷 第1期 页码 81-89 doi: 10.15302/J-FASE-2019291
The sustainable intensification of agriculture involves providing sufficient food and other ecosystem services without going beyond the limits of the earth’s system. Here a project management approach is suggested to help guide agricultural policy to deliver these objectives. The first step is to agree measurable outcomes, integrating formal policy goals with the often much less formal and much more diverse goals of individual farmers. The second step is to assess current performance. Ideally, this will involve the use of farm-scale metrics that can feed into process models that address social and environmental domains as well as production issues that can be benchmarked and upscaled to landscape and country. Some policy goals can be delivered by supporting ad hoc interventions, while others require the redesign of the farming system. A pipeline of research, knowledge and capacity building is needed to ensure the continuous increase in farm performance. System models can help prioritise policy interventions. Formal optimization of land use is only appropriate if the policy goals are clear, and the constraints understood. In practice, the best approach may depend on the scale of action that is required, and on the amount of resource and infrastructure available to generate, implement and manage policy.
关键词: agricultural policy ecosystem services indicators of sustainable intensification knowledge exchange land use optimization
标题 作者 时间 类型 操作
Zero E-waste: Regulatory impediments and blockchain imperatives
Mengjun Chen, Oladele A. Ogunseitan
期刊论文
Disinfection byproducts in drinking water and regulatory compliance: A critical review
Xiaomao WANG,Yuqin MAO,Shun TANG,Hongwei YANG,Yuefeng F. XIE
期刊论文
Analysis of the current situation of environmental policy of China and establishment of distributed environmentalpolicy framework
Chaoyang FU,Wangfeng LI
期刊论文
METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN
期刊论文
China’s policy framework for carbon capture, utilization and storage: Review, analysis, and outlook
期刊论文
Hierarchical methodological framework to improve Policy Environmental Assessment: Based on policy layer
Yinglie ZHOU, Cunkuan BAO,
期刊论文
Translating evidence into policy in China: opportunities and challenges
Jiyao Wang, Xuejuan Jin
期刊论文
METABOLIC AND TRANSCRIPTOME ANALYSIS REVEALS METABOLITE VARIATION AND FLAVONOID REGULATORY NETWORKS IN
Chen-Kai JIANG, De-Jiang NI, Ming-Zhe YAO, Jian-Qiang MA, Liang CHEN
期刊论文